In pharmaceutical manufacturing, solvents have multiple uses. They provide molecules for use as building blocks. For other drugs, solvents are used for extraction and purification, and they can provide a reaction medium. Frequently used at the beginning of the process to manufacture the active ingredients, they can also be used to help the final product achieve the proper consistency.
When solvents are used, flash fires and explosions are a very real threat to many manufacturers. Using nitrogen or other gases to create inert gas atmospheres is a widely used practice that reliably protects against flash fires and explosions. By continuously measuring oxygen levels and adding inert gas only as needed, our inerting control systems keep process units running at safe levels and enhance workplace safety by protecting plant personnel and plant assets.
The NFPA 69 Standard on Explosion Protection Systems recognizes oxidant concentration reduction as a method of protection based on preventing combustion. Requirements include maintaining the system at an oxygen concentration that is low enough to prevent a deflagration. Section 3.3.25 of the standard defines the limiting oxidant concentration (LOC) as the concentration of oxidant in a fuel-oxidant-diluent mixture below which a deflagration cannot occur.
Our inerting control systems (ICS) are designed to maintain the oxygen level at those levels. With field adjustable high and low limit setpoints, these systems can be utilized in many of the steps of the manufacturing process, ranging from production and product storage to packaging and transportation.
Applications can be found in solid dose and liquid processing and in both batch and continuous manufacturing. You will find our ICS installed on a variety of common types of equipment such as centrifuges, reactors, mixers, granulators, feeders, hoppers, and vapor collection headers.
In addition to the safety benefits, our systems are used to improve product quality by preventing contact with oxygen and moisture, providing the added benefits of lower production costs and increased profitability by efficiently limiting inert gas usage.
We are well aware of the challenges that you face when it comes to using and handling hazardous materials, meeting your safety goals, safeguarding product quality, and reducing production costs. Through the expertise of our team, we can help you and your business operate smarter, safer, and more economically.
Top Products
1100 Percent Oxygen Analyzer
The Neutronics 1100 Percent Oxygen Analyzer is a compact analyzer for oxygen gas measurement and process control applications. Designed for a measurement range of zero to 100% oxygen, the unit features a reliable electrochemical sensor that can be mounted remotely at the sampling point to ensure a fast response time. A flow-through mounting head allows the sensor to be horizontally or vertically mounted directly into the sampled process gas stream.
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5100 Percent Oxygen Analyzer
The Neutronics 5100 Percent Oxygen Analyzer is a compact analyzer designed for percent oxygen gas measurement. This analyzer features a rapid-response mini-zirconia sensor with a measurement range of 0 to 100% oxygen. Extremely high accuracy and single point calibration make this analyzer a low-maintenance solution that delivers reliable performance for critical process control applications.
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Sample Conditioning Packages
Neutronics Sample Conditioning Packages are designed to ensure that our oxygen sensors always have a clean and dry sample gas stream. Process conditions that include solvents, corrosive chemicals, and temperature extremes present significant challenges. To deliver accurate and reliable gas measurement, sensors require a sample that is free of contaminants. Sample conditioning systems built to withstand harsh processing conditions and efficiently remove damaging contaminants from the sample stream are critical to delivering reliable continuous-duty low-maintenance gas monitoring.
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